Role of CXCR7 and Effects on CXCL12 in SiHa Cells and Up-regulation in Cervical SCC in Uighur Women

Advanced cervical carcinoma (CC) is one of the most commonly diagnosed cancers in women, especially in developing countries, and it is still remains a major problem in oncology due to treatment failure and distant metastasis. Cervical cancer occurs with high morbidity and mortality in Uyghur women in the Xinjiang region, which is considered a high incidence disease in Xinjiang (Ma et al., 2001; Suzuk et al., 2006). Most patients in Xinjiang, at the time of diagnosis, already have locally advanced or metastatic disease, making surgical resection of the primary tumor of limited therapeutic value (Zhang et al., 2003). Detection of cancer cells in the lymph node is widely-recognized as one of the most important indicators of cervical cancer prognosis and guides the design of appropriate treatment strategies. Yet, the underlying molecular mechanisms that mediate the metastatic process leading to positive lymph node status in cervical cancer patients have yet to be fully elucidated. The formation of metastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven